Each level has its own individual tasks which will also grant stickers: completing a chore, defeating a henchman and solving puzzles.

Generally, there is a sticker for exiting every level, collecting 100 bones each level and rescuing all the puppies in each level. Various actions within the game will unlock stickers. Over the course of the game, the player has several opportunities to collect 'stickers' towards a virtual sticker book which can be accessed through the level menu. Source : The player can choose the role of Domino (voiced by Frankie Muniz in console versions) or Oddball. There are various levels in the game that are based on well-known places or monuments such as Regent's Park, Piccadilly, Big Ben and the Stonehenge. Similar to the film, the game is set in London, England. Instead the puppies set out to save their siblings, and their parents, who are captured along the way. Their parents, Dottie and Dipstick, set out to rescue their puppies, commanding Oddball and Domino to stay home.

Oddball and Domino are the only puppies in their family who have not been captured when they return from the park. Facing financial ruin from lack of sales, Cruella sets an evil plan in motion: to reprogram her toys to capture any pets in sight so she can freeze them in 'Super-Gloop' and sell them as a new line of realistic animal toys. They find a toy buried in a park that was made at one of Cruella de Vil's toy factories this alludes to the fact that Cruella's toy sales are down. Two Dalmatian puppies, Oddball and Domino, are out in the backyard looking for treasure. It is loosely based on the live-action Disney movie 102 Dalmatians. 102 Dalmatians: Puppies to the Rescue is a platform video game developed by Toys for Bob and published by Eidos Interactive for Microsoft Windows, PlayStation, Dreamcast and Game Boy color.

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